Trilostane2026-07-04T17:16:34-04:00

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A Drug Identification Number (DIN) is a unique eight-digit code assigned by Health Canada to drug products (prescription and over-the-counter) authorized for sale in Canada.

This site is provided as an information service for veterinary professionals and the owners of dogs who have been prescribed Vetoryl by their vet. Vetoryl is a prescription-only medicine, available only from your veterinarian. Any questions about your dog should be directed to your veterinary practice. Vetoryl is a registered trademark of Dechra Limited.

Vetoryl

Vetoryl Treatment

What is Vetoryl?

Vetoryl is the only veterinary-licensed treatment for both forms of Cushing’s disease in Canada. It contains the active ingredient trilostane, a drug which reduces the production of cortisol by the adrenal glands.

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Dos and Don’ts of Administering Vetoryl

Do:

  • Give Vetoryl capsules in the morning with food, so they can be easily absorbed. This also allows your veterinarian to carry out monitoring tests at the appropriate time of day.
  • Note your dog’s weight, water consumption, appetite and frequency of urination so you can monitor its improvement once treatment starts.
  • Contact your veterinarian immediately if your dog stops eating, drinking or urinating or becomes unwell while on Vetoryl.
  • Wash your hands after using Vetoryl.
  • Book follow-up appointments with your veterinarian every three months so that progress can be assessed.
  • You might consider taking a photo before you start treatment – improvements such as hair regrowth or the loss of a potbelly occur gradually so are less noticeable on a daily basis.

Don’t:

  • Split the capsules.
  • Give a double dose if you have forgotten a dose before. Consult your veterinarian.
  • Handle Vetoryl capsules if you are pregnant, or planning to become pregnant.
  • Change the daily dosage without consulting your veterinarian.
  • Stop administering the prescribed dosage of Vetoryl because you notice an improvement in the condition of your dog.

Resources

[Downloadable documents][Downloadable documents]

FAQ

Why do I have to give Vetoryl every day?2026-05-07T12:38:33-04:00

The active ingredient in Vetoryl is trilostane, a short-acting medicine which needs to be given every day to control the clinical signs.

How do I give Vetoryl to my dog?2026-05-07T12:38:59-04:00

It is recommended that you give your dog Vetoryl with a meal so that it can be easily absorbed. However you may disguise Vetoryl in a treat before feeding to ensure ease of administration, or add it to a small, tastier meal before feeding a reduced portion of regular food. If you are struggling to administer Vetoryl please consult with your vet. DO NOT open Vetoryl capsules – they should always be given whole.

How does Vetoryl work?2026-05-07T12:40:51-04:00

Vetoryl contains a drug called trilostane. Trilostane blocks an enzyme which is vital in the production of cortisol from the adrenal gland, which in turn lowers cortisol production. However, its effects are usually temporary therefore you must continue to administer Vetoryl, even if your dog appears to be fully improved. Without a constant supply of Vetoryl, cortisol production will increase and your dog may start to display symptoms of Cushing’s once more.

How long after I start Vetoryl should I expect to see an improvement?2026-05-07T12:41:28-04:00

For most dogs the effects of Vetoryl are seen quite quickly. It is usually the case that the signs of increased drinking and urinating improve quickly, within a couple of weeks on therapy. However, some changes will take longer to resolve; a potbellied appearance is a good example of this, and some may even worsen before they start to improve, such as hair loss. You can track your dog’s improvement by using the logbook. Please contact your veterinarian if you feel your dog is not improving as you would expect.

What should I do if I forget to give a capsule?2026-05-07T12:41:51-04:00

Contact your veterinarian. DO NOT give a double dose the next day.

What should I do if my dog gets an accidental overdose of Vetoryl?2026-05-07T12:42:20-04:00

Contact your veterinarian IMMEDIATELY. Vetoryl is rapidly absorbed from the gastrointestinal tract therefore it is vital that you get professional advice as soon as possible. Your vet will advise you on the best course of action dependent on how much Vetoryl your dog has eaten and the time since the overdose occurred. It is useful to have this information ready for your vet. Key signs to look out for after an overdose include lethargy, anorexia, vomiting, diarrhea and collapse. You should present your dog for veterinary attention immediately should such signs occur.

Does Vetoryl have any side effects?2026-05-07T12:42:44-04:00

Vetoryl is well tolerated by most dogs. If your dog develops any signs of illness whilst on Vetoryl including lethargy, vomiting, diarrhea and anorexia, stop treatment immediately and contact your veterinarian as soon as possible.

How do I stop Vetoryl?2026-05-07T12:43:11-04:00

Once on treatment, most patients will require Vetoryl for the rest of their lives. Therefore unless you are otherwise instructed by your veterinarian, you should continue to give Vetoryl at the dose and frequency recommended by your vet. The exception to this rule would be if your dog develops any signs of illness whilst on Vetoryl including lethargy, vomiting, diarrhea and anorexia. In these cases stop treatment immediately and contact your veterinarian as soon as possible.

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